Annual report pursuant to Section 13 and 15(d)

Income Taxes - Schedule of Significant Components of Net Deferred Tax Assets (Detail)

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Income Taxes - Schedule of Significant Components of Net Deferred Tax Assets (Detail) - USD ($)
$ in Thousands
Dec. 31, 2015
Dec. 31, 2014
Income Tax Disclosure [Abstract]    
Capitalized start-up costs $ 103 $ 128
Net operating loss carryforwards 47,725 33,049
Research and development credits 11,354 6,616
Deferred stock compensation 5,130 3,933
Deferred revenue 0 26,151
Other (accruals, reserves, depreciation) 359 1,019
Total deferred tax assets 64,671 70,896
Less: Valuation allowance $ (64,671) $ (70,896)