Annual report pursuant to Section 13 and 15(d)

Income Taxes - Schedule of Reconciliation of Income Taxes at Statutory Federal Income Tax Rate to Net Income Taxes (Detail)

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Income Taxes - Schedule of Reconciliation of Income Taxes at Statutory Federal Income Tax Rate to Net Income Taxes (Detail) - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Income Tax Disclosure [Abstract]      
U.S. federal taxes (benefit) at statutory rate $ 14,900,000 $ (7,407,000) $ (9,592,000)
State federal income tax benefit (448,000) (571,000) (1,794,000)
Unutilized (utilized) net operating losses (11,287,000) 9,809,000 9,747,000
Stock-based compensation 898,000 730,000 486,000
Research and development credits (3,135,000) (952,000) (1,416,000)
Tax assets not benefited 4,732,000 1,322,000 1,926,000
Nondeductible warrant expense (5,703,000) (3,177,000) 790,000
Other 43,000 44,000 55,000
Total $ 0 $ (202,000) $ 202,000