Annual report pursuant to Section 13 and 15(d)

Equity Incentive Plans and Stock Based Compensation - Stock-Based Compensation Expense (Detail)

v2.4.1.9
Equity Incentive Plans and Stock Based Compensation - Stock-Based Compensation Expense (Detail) (USD $)
In Thousands, unless otherwise specified
0 Months Ended 12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]            
Stock-based compensation expense $ 5,400us-gaap_AllocatedShareBasedCompensationExpense $ 4,800us-gaap_AllocatedShareBasedCompensationExpense $ 2,800us-gaap_AllocatedShareBasedCompensationExpense $ 5,488us-gaap_AllocatedShareBasedCompensationExpense $ 4,922us-gaap_AllocatedShareBasedCompensationExpense $ 3,010us-gaap_AllocatedShareBasedCompensationExpense
Research and Development            
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]            
Stock-based compensation expense       3,123us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember
2,562us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember
1,521us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember
General and Administrative            
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]            
Stock-based compensation expense       $ 2,365us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_GeneralAndAdministrativeExpenseMember
$ 2,360us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_GeneralAndAdministrativeExpenseMember
$ 1,489us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_GeneralAndAdministrativeExpenseMember