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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified |
12 Months Ended | ||
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Dec. 31, 2014
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Dec. 31, 2013
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Dec. 31, 2012
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| Cash flows from operating activities: | |||
| Net loss | $ (21,584)us-gaap_NetIncomeLoss | $ (28,415)us-gaap_NetIncomeLoss | $ (71,135)us-gaap_NetIncomeLoss |
| Adjustments to reconcile net loss to net cash used in operating activities: | |||
| Depreciation and amortization | 1,309us-gaap_DepreciationAndAmortization | 1,506us-gaap_DepreciationAndAmortization | 1,008us-gaap_DepreciationAndAmortization |
| Stock-based compensation expense | 5,488us-gaap_ShareBasedCompensation | 4,922us-gaap_ShareBasedCompensation | 3,010us-gaap_ShareBasedCompensation |
| Change in common stock warrant value | (9,344)us-gaap_GainLossOnDerivativeInstrumentsNetPretax | 2,325us-gaap_GainLossOnDerivativeInstrumentsNetPretax | 51,216us-gaap_GainLossOnDerivativeInstrumentsNetPretax |
| (Gain) loss on sale of investments, property and equipment | (3)us-gaap_GainLossOnDispositionOfAssets1 | (5)us-gaap_GainLossOnDispositionOfAssets1 | |
| Changes in operating assets and liabilities: | |||
| Collaboration receivable | 10,846us-gaap_IncreaseDecreaseInOtherReceivables | (2,459)us-gaap_IncreaseDecreaseInOtherReceivables | (15,635)us-gaap_IncreaseDecreaseInOtherReceivables |
| Prepaid expenses and other current assets | 1,314us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets | (1,079)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets | (623)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets |
| Accounts payable | 385us-gaap_IncreaseDecreaseInAccountsPayable | 781us-gaap_IncreaseDecreaseInAccountsPayable | (1,481)us-gaap_IncreaseDecreaseInAccountsPayable |
| Accrued clinical and development expenses | (1,446)thld_IncreaseDecreaseInAccruedClinicalAndDevelopmentLiabilities | 1,694thld_IncreaseDecreaseInAccruedClinicalAndDevelopmentLiabilities | 1,285thld_IncreaseDecreaseInAccruedClinicalAndDevelopmentLiabilities |
| Accrued liabilities | 19us-gaap_IncreaseDecreaseInAccruedLiabilities | 904us-gaap_IncreaseDecreaseInAccruedLiabilities | 520us-gaap_IncreaseDecreaseInAccruedLiabilities |
| Deferred rent | 3us-gaap_IncreaseDecreaseInDeferredCharges | (28)us-gaap_IncreaseDecreaseInDeferredCharges | 115us-gaap_IncreaseDecreaseInDeferredCharges |
| Deferred revenue | (14,722)us-gaap_IncreaseDecreaseInDeferredRevenue | 30,005us-gaap_IncreaseDecreaseInDeferredRevenue | 61,633us-gaap_IncreaseDecreaseInDeferredRevenue |
| Net cash provided by (used in) operating activities | (27,735)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations | 10,151us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations | 29,913us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations |
| Cash flows from investing activities: | |||
| Acquisition of property and equipment | (224)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment | (158)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment | (482)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment |
| Acquisition of marketable securities | (44,911)us-gaap_PaymentsToAcquireAvailableForSaleSecurities | (101,968)us-gaap_PaymentsToAcquireAvailableForSaleSecurities | (93,745)us-gaap_PaymentsToAcquireAvailableForSaleSecurities |
| Proceeds from sales of marketable securities | 14,584us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities | 5,338us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities | 14,266us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities |
| Proceeds from maturities of marketable securities | 53,878us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities | 80,495us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities | 33,285us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities |
| Net cash provided by (used in) investing activities | 23,327us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations | (16,293)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations | (46,676)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations |
| Cash flows from financing activities: | |||
| Proceeds from issuance of common stock and warrants, net of offering expenses | 5,520us-gaap_ProceedsFromIssuanceOfCommonStock | 2,392us-gaap_ProceedsFromIssuanceOfCommonStock | 21,910us-gaap_ProceedsFromIssuanceOfCommonStock |
| Net cash provided by financing activities | 5,520us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations | 2,392us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations | 21,910us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations |
| Net increase (decrease) in cash and cash equivalents | 1,112us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease | (3,750)us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease | 5,147us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease |
| Cash and cash equivalents, beginning of period | 7,279us-gaap_CashAndCashEquivalentsAtCarryingValue | 11,029us-gaap_CashAndCashEquivalentsAtCarryingValue | 5,882us-gaap_CashAndCashEquivalentsAtCarryingValue |
| Cash and cash equivalents, end of period | 8,391us-gaap_CashAndCashEquivalentsAtCarryingValue | 7,279us-gaap_CashAndCashEquivalentsAtCarryingValue | 11,029us-gaap_CashAndCashEquivalentsAtCarryingValue |
| Non-cash investing and financing activities: | |||
| Change in unrealized gain (loss) in marketable securities | $ (41)us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGainLoss1 | $ 17us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGainLoss1 | $ 12us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGainLoss1 |
| X | ||||||||||
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- Definition
Increase decrease in accrued clinical and development liabilities. No definition available.
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| X | ||||||||||
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- Details
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| X | ||||||||||
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- Definition
Amount of unrealized gain (loss) on investments in debt and equity securities classified as available-for-sale securities. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
Amount of increase (decrease) in cash and cash equivalents. Cash and cash equivalents are the amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Includes effect from exchange rate changes. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The current period expense charged against earnings on long-lived, physical assets not used in production, and which are not intended for resale, to allocate or recognize the cost of such assets over their useful lives; or to record the reduction in book value of an intangible asset over the benefit period of such asset; or to reflect consumption during the period of an asset that is not used in production. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
Aggregate net gain (loss) on all derivative instruments recognized in earnings during the period, before tax effects. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
Amount of gain (loss) on sale or disposal of assets, including but not limited to property plant and equipment, intangible assets and equity in securities of subsidiaries or equity method investee. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The increase (decrease) during the reporting period in the aggregate amount of liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received that are used in an entity's business. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The increase (decrease) during the reporting period in the aggregate amount of expenses incurred but not yet paid. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The increase (decrease) during the reporting period in the value of expenditures made during the current reporting period for benefits that will be received over a period of years. Deferred charges differ from prepaid expenses in that they usually extend over a long period of time and may or may not be regularly recurring costs of operation. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The increase (decrease) during the reporting period, excluding the portion taken into income, in the liability reflecting revenue yet to be earned for which cash or other forms of consideration was received or recorded as a receivable. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Details
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| X | ||||||||||
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- Definition
The increase (decrease) during the reporting period in other amounts due to the reporting entity, which are not otherwise defined in the taxonomy. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The increase (decrease) during the reporting period in the value of prepaid expenses and other assets not separately disclosed in the statement of cash flows, for example, deferred expenses, intangible assets, or income taxes. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Details
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| X | ||||||||||
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- Definition
Amount of cash inflow (outflow) of financing activities, excluding discontinued operations. Financing activity cash flows include obtaining resources from owners and providing them with a return on, and a return of, their investment; borrowing money and repaying amounts borrowed, or settling the obligation; and obtaining and paying for other resources obtained from creditors on long-term credit. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Details
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| X | ||||||||||
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- Definition
Amount of cash inflow (outflow) of investing activities, excluding discontinued operations. Investing activity cash flows include making and collecting loans and acquiring and disposing of debt or equity instruments and property, plant, and equipment and other productive assets. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Details
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| X | ||||||||||
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- Definition
Amount of cash inflow (outflow) from operating activities, excluding discontinued operations. Operating activity cash flows include transactions, adjustments, and changes in value not defined as investing or financing activities. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The portion of profit or loss for the period, net of income taxes, which is attributable to the parent. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Details
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| X | ||||||||||
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- Definition
The cash outflow to acquire debt and equity securities not classified as either held-to-maturity securities or trading securities which would be classified as available-for-sale securities and reported at fair value, with unrealized gains and losses excluded from earnings and reported in a separate component of shareholders' equity. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The cash inflow from the additional capital contribution to the entity. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The cash inflow associated with maturities (principal being due), prepayments and calls (requests of early payments) on securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The cash inflow associated with the sale of debt and equity securities classified as available-for-sale securities. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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