Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT)

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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT) (USD $)
In Thousands, except Share data
Total
Common Stock [Member]
Additional Paid-In Capital [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Deficit [Member]
Balances, value at Dec. 31, 2009 $ 22,657 $ 33 $ 230,441 $ (24) $ (207,793)
Balances, shares at Dec. 31, 2009   33,563,670      
Issuance of common stock pursuant to stock plans, value 140 1 139    
Issuance of common stock pursuant to stock plans, shares   138,572      
Stock-based compensation 803   803    
Change in unrealized gain (loss) on marketable securities 25     25  
Net loss (18,682)       (18,682)
Balances, value at Dec. 31, 2010 4,943 34 231,383 1 (226,475)
Balances, shares at Dec. 31, 2010   33,702,242      
Issuance of common stock to certain investors, net of issuance costs of $0.4 million & $2.5 million for 2012 & 2011 respectively 24,007 15 23,992    
Issuance of common stock to certain investors, net of issuance costs, shares   15,284,118      
Issuance of common stock pursuant to stock plans, value 149   149    
Issuance of common stock pursuant to stock plans, shares   142,115      
Stock-based compensation 1,039   1,039    
Change in unrealized gain (loss) on marketable securities (2)     (2)  
Net loss (25,653)       (25,653)
Balances, value at Dec. 31, 2011 4,483 49 256,563 (1) (252,128)
Balances, shares at Dec. 31, 2011 49,128,475 49,128,475      
Issuance of common stock to certain investors, net of issuance costs of $0.4 million & $2.5 million for 2012 & 2011 respectively 12,323 2 12,321    
Issuance of common stock to certain investors, net of issuance costs, shares   2,022,144      
Exercise of warrants to purchase common stock   4,727,331      
Exercise of warrants to purchase common stock, value 8,849 5 8,844    
Issuance of common stock pursuant to stock plans, value 738   738    
Issuance of common stock pursuant to stock plans, shares   553,257      
Stock-based compensation 3,010   3,010    
Reclassification of fair value of warrants exercised from liability to equity 27,867   27,867    
Change in unrealized gain (loss) on marketable securities 12     12  
Net loss (71,135)       (71,135)
Balances, value at Dec. 31, 2012 $ (13,853) $ 56 $ 309,343 $ 11 $ (323,263)
Balances, shares at Dec. 31, 2012 56,431,207 56,431,207