Annual report pursuant to Section 13 and 15(d)

Income Taxes - Schedule of Reconciliation of Income Taxes at Statutory Federal Income Tax Rate to Net Income Taxes (Detail)

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Income Taxes - Schedule of Reconciliation of Income Taxes at Statutory Federal Income Tax Rate to Net Income Taxes (Detail) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Income Tax Disclosure [Abstract]    
U.S. federal taxes (benefit) at statutory rate $ (6,361,000) $ (7,867,000)
State federal income tax benefit (69,000) (21,000)
Permanent differences (24,000) 87,000
Research and development credits (608,000) (237,000)
Change in valuation allowance due to operations 2,758,000 4,766,000
Acquisition-related permanent differences 0 2,281,000
Expiring state carryovers and other 4,304,000 991,000
Change in valuation allowance due to Tax Act 0 (6,863,000)
U.S. Statutory Rate Change due to Tax Act 0 6,863,000
Total $ 0 $ 0