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Condensed Consolidated Balance Sheets (USD $)
In Thousands, unless otherwise specified |
Mar. 31, 2015
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Dec. 31, 2014
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|---|---|---|
| Current assets: | ||
| Cash and cash equivalents | $ 21,063us-gaap_CashAndCashEquivalentsAtCarryingValue | $ 8,391us-gaap_CashAndCashEquivalentsAtCarryingValue |
| Marketable securities, current | 57,822us-gaap_AvailableForSaleSecuritiesCurrent | 50,209us-gaap_AvailableForSaleSecuritiesCurrent |
| Collaboration receivable | 1,993us-gaap_OtherReceivables | 7,248us-gaap_OtherReceivables |
| Prepaid expenses and other current assets | 1,226us-gaap_PrepaidExpenseAndOtherAssetsCurrent | 832us-gaap_PrepaidExpenseAndOtherAssetsCurrent |
| Total current assets | 82,104us-gaap_AssetsCurrent | 66,680us-gaap_AssetsCurrent |
| Marketable securities, non-current | 4,201us-gaap_MarketableSecuritiesNoncurrent | |
| Property and equipment, net | 503us-gaap_PropertyPlantAndEquipmentNet | 557us-gaap_PropertyPlantAndEquipmentNet |
| Other assets | 1,201us-gaap_OtherAssetsNoncurrent | 1,159us-gaap_OtherAssetsNoncurrent |
| Total assets | 88,009us-gaap_Assets | 68,396us-gaap_Assets |
| Current liabilities: | ||
| Accounts payable | 1,809us-gaap_AccountsPayableCurrent | 2,074us-gaap_AccountsPayableCurrent |
| Accrued clinical and development expenses | 8,248thld_AccruedClinicalAndDevelopmentLiabilities | 5,998thld_AccruedClinicalAndDevelopmentLiabilities |
| Accrued liabilities | 4,196us-gaap_AccruedLiabilitiesCurrent | 3,180us-gaap_AccruedLiabilitiesCurrent |
| Deferred revenue, current | 14,722us-gaap_DeferredRevenueCurrent | 14,722us-gaap_DeferredRevenueCurrent |
| Total current liabilities | 28,975us-gaap_LiabilitiesCurrent | 25,974us-gaap_LiabilitiesCurrent |
| Warrant liability | 20,185us-gaap_DerivativeLiabilitiesNoncurrent | 3,961us-gaap_DerivativeLiabilitiesNoncurrent |
| Deferred revenue, non-current | 58,513us-gaap_DeferredRevenueNoncurrent | 62,194us-gaap_DeferredRevenueNoncurrent |
| Deferred rent | 225us-gaap_DeferredRentCreditNoncurrent | 243us-gaap_DeferredRentCreditNoncurrent |
| Total liabilities | 107,898us-gaap_Liabilities | 92,372us-gaap_Liabilities |
| Commitments and contingencies (Note 7) | ||
| Stockholders’ equity (deficit): | ||
| Preferred stock, $0.001 par value, 2,000,000 shares authorized; no shares issued and outstanding | ||
| Common stock, $0.001 par value, shares authorized: 150,000,000 shares; issued and outstanding: 71,334,362 shares at March 31, 2015 and 62,898,233 shares at December 31, 2014 | 71us-gaap_CommonStockValue | 63us-gaap_CommonStockValue |
| Additional paid-in capital | 364,471us-gaap_AdditionalPaidInCapitalCommonStock | 349,236us-gaap_AdditionalPaidInCapitalCommonStock |
| Accumulated other comprehensive gain (loss) | (15)us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax | (13)us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax |
| Accumulated deficit | (384,416)us-gaap_RetainedEarningsAccumulatedDeficit | (373,262)us-gaap_RetainedEarningsAccumulatedDeficit |
| Total stockholders’ equity (deficit) | (19,889)us-gaap_StockholdersEquity | (23,976)us-gaap_StockholdersEquity |
| Total liabilities and stockholders’ equity (deficit) | $ 88,009us-gaap_LiabilitiesAndStockholdersEquity | $ 68,396us-gaap_LiabilitiesAndStockholdersEquity |
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- Definition
Accruals for clinical trial and development expenses. No definition available.
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- Definition
Carrying value as of the balance sheet date of liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received that are used in an entity's business. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Accumulated change in equity from transactions and other events and circumstances from non-owner sources, net of tax effect, at period end. Excludes Net Income (Loss), and accumulated changes in equity from transactions resulting from investments by owners and distributions to owners. Includes foreign currency translation items, certain pension adjustments, unrealized gains and losses on certain investments in debt and equity securities, other than temporary impairment (OTTI) losses related to factors other than credit losses on available-for-sale and held-to-maturity debt securities that an entity does not intend to sell and it is not more likely than not that the entity will be required to sell before recovery of the amortized cost basis, as well as changes in the fair value of derivatives related to the effective portion of a designated cash flow hedge. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Value received from shareholders in common stock-related transactions that are in excess of par value or stated value and amounts received from other stock-related transactions. Includes only common stock transactions (excludes preferred stock transactions). May be called contributed capital, capital in excess of par, capital surplus, or paid-in capital. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Sum of the carrying amounts as of the balance sheet date of all assets that are recognized. Assets are probable future economic benefits obtained or controlled by an entity as a result of past transactions or events. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Sum of the carrying amounts as of the balance sheet date of all assets that are expected to be realized in cash, sold, or consumed within one year (or the normal operating cycle, if longer). Assets are probable future economic benefits obtained or controlled by an entity as a result of past transactions or events. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Details
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- Definition
Amount of investment in debt and equity securities categorized neither as trading securities nor held-to-maturity securities and intended be sold or mature one year or operating cycle, if longer. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Represents the caption on the face of the balance sheet to indicate that the entity has entered into (1) purchase or supply arrangements that will require expending a portion of its resources to meet the terms thereof, and (2) is exposed to potential losses or, less frequently, gains, arising from (a) possible claims against a company's resources due to future performance under contract terms, and (b) possible losses or likely gains from uncertainties that will ultimately be resolved when one or more future events that are deemed likely to occur do occur or fail to occur. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Aggregate par or stated value of issued nonredeemable common stock (or common stock redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable common shares, par value and other disclosure concepts are in another section within stockholders' equity. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
For a classified balance sheet, the cumulative difference between the rental income or payments required by a lease agreement and the rental income or expense recognized on a straight-line basis, or other systematic and rational basis more representative of the time pattern in which use or benefit is granted or derived from the leased property, expected to be recognized in income or expense, by the lessor or lessee, respectively, more than one year after the balance sheet date. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
The carrying amount of consideration received or receivable as of the balance sheet date on potential earnings that were not recognized as revenue in conformity with GAAP, and which are expected to be recognized as such within one year or the normal operating cycle, if longer, including sales, license fees, and royalties, but excluding interest income. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
The noncurrent portion of deferred revenue amount as of balance sheet date. Deferred revenue is a liability related to a revenue producing activity for which revenue has not yet been recognized, and is not expected to be recognized in the next twelve months. Generally, an entity records deferred revenue when it receives consideration from a customer before achieving certain criteria that must be met for revenue to be recognized in conformity with GAAP. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Fair value, after the effects of master netting arrangements, of a financial liability or contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset, expected to be settled after one year or the normal operating cycle, if longer. Includes assets not subject to a master netting arrangement and not elected to be offset. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Sum of the carrying amounts as of the balance sheet date of all liabilities that are recognized. Liabilities are probable future sacrifices of economic benefits arising from present obligations of an entity to transfer assets or provide services to other entities in the future. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Amount of liabilities and equity items, including the portion of equity attributable to noncontrolling interests, if any. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Total obligations incurred as part of normal operations that are expected to be paid during the following twelve months or within one business cycle, if longer. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Details
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- Definition
Total debt and equity financial instruments including: (1) securities held-to-maturity and (2) securities available-for-sale that will be held for the long-term. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Aggregate carrying amount, as of the balance sheet date, of noncurrent assets not separately disclosed in the balance sheet. Noncurrent assets are expected to be realized or consumed after one year (or the normal operating cycle, if longer). Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Carrying amounts due as of the balance sheet date from parties or arising from transactions not otherwise specified in the taxonomy. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
Aggregate par or stated value of issued nonredeemable preferred stock (or preferred stock redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable preferred shares, par value and other disclosure concepts are in another section within stockholders' equity. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
Amount of asset related to consideration paid in advance for costs that provide economic benefits in future periods, and amount of other assets that are expected to be realized or consumed within one year or the normal operating cycle, if longer. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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| X | ||||||||||
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- Definition
The cumulative amount of the reporting entity's undistributed earnings or deficit. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition
Total of all stockholders' equity (deficit) items, net of receivables from officers, directors, owners, and affiliates of the entity which are attributable to the parent. The amount of the economic entity's stockholders' equity attributable to the parent excludes the amount of stockholders' equity which is allocable to that ownership interest in subsidiary equity which is not attributable to the parent (noncontrolling interest, minority interest). This excludes temporary equity and is sometimes called permanent equity. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Details
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