Annual report pursuant to Section 13 and 15(d)

Commitments and Contingencies - Additional Information (Detail)

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Commitments and Contingencies - Additional Information (Detail) (USD $)
12 Months Ended 1 Months Ended 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Nov. 30, 2013
South San Francisco, California [Member]
sqft
Dec. 31, 2013
South San Francisco, California [Member]
sqft
Other Commitments [Line Items]          
Square feet of laboratory space and office space       7,934 28,650
Lease agreement expiration date       Dec. 31, 2016 Apr. 30, 2017
Aggregate rent over life of lease       $ 700,000 $ 3,400,000
Security deposit for lease         60,000
Rent expense 600,000 700,000 1,300,000    
Purchase commitments $ 2,600,000