Quarterly report pursuant to Section 13 or 15(d)

Collaboration Arrangements - Additional Information (Detail)

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Collaboration Arrangements - Additional Information (Detail) - Merck KGaA - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Sep. 30, 2015
Sep. 30, 2014
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Upfront and milestone payments received to date     $ 110,000,000  
Revenue recognized by the Company $ 3,700,000 $ 3,700,000 11,000,000 $ 11,000,000
Company received a reimbursement for eligible worldwide development expenses $ 3,800,000 $ 4,800,000 $ 9,500,000 $ 14,200,000
United States        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Portion of profits that Company is eligible to participate, depending upon total sales     50.00%  
Regulatory and Development Milestones | Maximum        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Potential future milestones     $ 100,000,000  
Commercialization Milestones | Maximum        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Potential future milestones     $ 340,000,000  
Collaborative Arrangement Product Agreement | Evofosfamide        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Merck KGaA's percentage share of worldwide development expenses     70.00%