Quarterly report pursuant to Section 13 or 15(d)

Research and Development Agreements - Schedule of Impact of Adoption on Condensed Consolidated Statement of Operations and Comprehensive (Detail)

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Research and Development Agreements - Schedule of Impact of Adoption on Condensed Consolidated Statement of Operations and Comprehensive (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Revenue Recognition [Line Items]    
Research and development revenue $ 231 $ 1,760
Total revenue 482 1,885
Net loss $ 8,714 $ 1,195
Basic and diluted $ 0.32 $ 7.56
ASC 2014-09 | Effect of Adoption of ASC 606    
Revenue Recognition [Line Items]    
Research and development revenue $ (68)  
Total revenue (68)  
Net loss $ 68  
Basic and diluted $ 0.01  
ASC 2014-09 | Balance without Adoption of ASC 606    
Revenue Recognition [Line Items]    
Research and development revenue $ 163  
Total revenue 414  
Net loss $ 8,782  
Basic and diluted $ 0.33