Promising Therapy for HER2 Cancer Patients
MT-5111 is a second generation engineered toxin body (ETB) consisting of a single-chain variable fragment (scFv) with an affinity for HER2, fused to the enzymatically active de-immunized Shiga-like toxin-A subunit (SLTA). MT-5111 specifically binds and kills HER2 expressing cells in a manner consistent with SLTA mediated cellular cytotoxicity.
MT-5111 is designed to avoid competition with and to overcome the primary mechanisms of tumor resistance to current HER2 targeted therapies. MT-5111 may provide benefits to patients with HER2-positive cancers by potentially overcoming mechanisms of tumor resistance to existing HER2 targeted therapies.