FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
PEQUOT CAPITAL MANAGEMENT INC
  2. Issuer Name and Ticker or Trading Symbol
THRESHOLD PHARMACEUTICALS INC [THLD]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
_____ Officer (give title below) __X__ Other (specify below)
See Footnote 1
(Last)
(First)
(Middle)
500 NYALA FARM ROAD
3. Date of Earliest Transaction (Month/Day/Year)
09/29/2006
(Street)

WESTPORT, CT 06880
4. If Amendment, Date Original Filed(Month/Day/Year)
09/29/2006
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right-to-buy) $ 2.57 (5) 09/29/2006(5)   A   15,000 (2) (3)     (3) 05/19/2015(3) Common Stock 15,000 (2) (3) (3) 15,000 (2) (3) I (2) Investment Advisor (1)
Stock Option (Right-to-buy) $ 2.57 (5) 09/29/2006(5)   A   15,000 (2) (4)     (4) 05/24/2016(4) Common Stock 15,000 (2) (4) (4) 15,000 (2) (4) I (2) Investment Advisor (1)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
PEQUOT CAPITAL MANAGEMENT INC
500 NYALA FARM ROAD
WESTPORT, CT 06880
      See Footnote 1
ENRIGHT PATRICK G
500 NYALA FARM ROAD
WESTPORT, CT 06880
  X      

Signatures

 Aryeh Davis, GC & COO, Pequot Capital Management, Inc.   10/03/2006
**Signature of Reporting Person Date

 Patrick G. Enright, Director (1)   10/03/2006
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Pequot Capital Management, Inc. ("Pequot") is an investment advisor registered under Section 203 of the Investment Advisers Act of 1940 and has voting and investment power with respect to securities in its clients' accounts. Pequot disclaims any obligation to file this report, and this report shall not be deemed an admission that Pequot is subject to Section 16 with respect to the Issuer of such securities. Patrick G. Enright is an employee of Pequot and serves on the Board of Directors of the Issuer and disclaims beneficial ownership of these securities except to the extent of his pecuniary interest.
(2) Pequot disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that Pequot is, for the purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of such securities.
(3) As described in a previous filing, the Issuer cancelled, pursuant to the Issuer's Option Exchange Program (the "Program"), an Option granted to the Reporting Person on May 19, 2005. In exchange, the Reporting Person received a replacement option on September 29, 2006 to purchase 15,000 shares of the Issuer's common stock, with an exercise price of $2.57, and vesting in equal monthly installments until the Issuer's next annual stockholder meeting (the "Replacement Option"), whereby the Replacement Option will become fully vested. The Replacement Option expires on May 19, 2015.
(4) As described in a previous filing, the Issuer cancelled, pursuant to the Issuer's Option Exchange Program (the "Program"), an Option granted to the Reporting Person on May 25, 2006. In exchange, the Reporting Person received a replacement option on September 29, 2006 to purchase 15,000 shares of the Issuer's common stock, with an exercise price of $2.57, and vesting in equal monthly installments until the Issuer's next annual stockholder meeting (the "Replacement Option"), whereby the Replacement Option will become fully vested. The Replacement Option expires on May 24, 2016.
(5) This amendment to Form 4 amends the Form 4 filed on September 29, 2006 (rather than September 27, 2006 as previously reported) to reflect the accurate grant date of September 29, 2006 and to reflect the accurate exercise price of $2.57 (rather than $2.50 as previously reported).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.