Quarterly report pursuant to Section 13 or 15(d)

Research and Development Agreements - Additional Information (Detail)

v3.10.0.1
Research and Development Agreements - Additional Information (Detail) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended 83 Months Ended
Sep. 18, 2018
Aug. 31, 2017
Jun. 23, 2017
Oct. 31, 2018
Jul. 31, 2018
Jun. 30, 2018
Sep. 30, 2016
Nov. 30, 2011
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Sep. 30, 2018
Oct. 31, 2016
Research And Development Collaboration Agreements [Line Items]                              
Revenue remaining performance obligations not yet satisfied                 $ 33,600,000   $ 33,600,000     $ 33,600,000  
Receivables from Customers                 31,400,000   31,400,000   $ 0 31,400,000  
Research and development revenue                 2,031,000 $ 648,000 3,206,000 $ 2,408,000      
Total revenue                 6,752,000   8,601,000        
Deferred revenue                 33,400,000   33,400,000   2,765,000 33,400,000  
Grant                              
Research And Development Collaboration Agreements [Line Items]                              
Revenue from grant                 4,700,000 0 5,400,000 167,000      
CPRIT Agreement | Grant                              
Research And Development Collaboration Agreements [Line Items]                              
Cancer research grant contract award $ 15,200,000                            
Takeda Pharmaceuticals Inc                              
Research And Development Collaboration Agreements [Line Items]                              
Accounts receivable                 31,200,000   31,200,000     31,200,000  
Aggregate Purchase Price     $ 20,000,000                        
Takeda Development Agreement                              
Research And Development Collaboration Agreements [Line Items]                              
Commercial milestone payment                     150,000,000        
Cancer Prevention and Research Institute of Texas | Grant Agreements | ETB MT-3724                              
Research And Development Collaboration Agreements [Line Items]                              
Product development grant awarded               $ 10,600,000              
Aggregate proceeds received from award granted                           9,500,000  
Takeda Individual Project Agreement                              
Research And Development Collaboration Agreements [Line Items]                              
Cumulative catch-up adjustment to revenue                 180,000   180,000        
Takeda Individual Project Agreement | Takeda Pharmaceuticals Inc                              
Research And Development Collaboration Agreements [Line Items]                              
Additional research and development revenue entitled to potentially receive           $ 2,200,000                  
Increase in transaction consideration related to research services         $ 1,100,000                    
Research and development revenue                 1,200,000 0 1,900,000 0      
Accounts receivable                 1,200,000   1,200,000     1,200,000  
Takeda Collaboration Agreement | Takeda Pharmaceuticals Inc                              
Research And Development Collaboration Agreements [Line Items]                              
Payment for technology access fees and cost reimbursement                             $ 2,000,000
Research and development revenue                 0 648,000 92,000 1,900,000      
Takeda Development Agreement                              
Research And Development Collaboration Agreements [Line Items]                              
Research and development revenue                 0 0 0 0      
Accounts receivable                 30,000,000   30,000,000     30,000,000  
Total transaction price                     29,300,000        
Upfront payment                     30,000,000        
Milestone payment received                     10,000,000        
Expected co share payment receivable                 10,700,000   10,700,000     10,700,000  
Total revenue                 253,000   253,000        
Deferred revenue                 28,800,000   28,800,000     28,800,000  
Takeda Development Agreement | Clinical Development and Regulatory Milestones                              
Research And Development Collaboration Agreements [Line Items]                              
Milestone payments receivable if option is exercised                     307,500,000        
Milestone payments receivable if option is not exercised                     162,500,000        
Takeda Development Agreement | Sales Milestone                              
Research And Development Collaboration Agreements [Line Items]                              
Milestone payments receivable if option is exercised                     325,000,000        
Milestone payments receivable if option is not exercised                     175,000,000        
Takeda Development Agreement | Subsequent Event                              
Research And Development Collaboration Agreements [Line Items]                              
Upfront payment received       $ 30,000,000                      
Takeda Multi Target Agreement | Takeda Pharmaceuticals Inc                              
Research And Development Collaboration Agreements [Line Items]                              
Research and development revenue                 415,000 0 755,000 0      
Upfront payment received                     1,000,000        
Additional contingent milestone payments upon designation of each of two targets                 2,000,000   2,000,000     2,000,000  
Accounts received from Takeda                     5,000,000   $ 5,000,000    
Aggregate milestone payments upon exercise of option to license ETBS                 25,000,000   25,000,000     25,000,000  
Additional preclinical, clinical development and commercialization milestone payments entitled to potentially receive                 397,000,000   397,000,000     397,000,000  
Contractual contingency fees                     10,000,000        
Proceeds from signing of stock purchase agreement                   20,000,000          
Aggregate Purchase Price   $ 20,000,000                          
Other Collaboration Agreements                              
Research And Development Collaboration Agreements [Line Items]                              
Research and development revenue                 117,000 $ 0 196,000 $ 500,000      
Other Collaboration Agreements | ETBs                              
Research And Development Collaboration Agreements [Line Items]                              
Research and development revenue             $ 500,000                
Contingent milestone payment upon delivery and acceptance of additional ETB materials                 $ 250,000   $ 250,000     $ 250,000