Annual report pursuant to Section 13 and 15(d)

Equity Incentive Plans and Stock Based Compensation - Stock-Based Compensation Expense (Detail)

v3.7.0.1
Equity Incentive Plans and Stock Based Compensation - Stock-Based Compensation Expense (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense $ 3,089 $ 6,801 $ 5,488
Research and Development      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense 1,281 4,090 3,123
General and Administrative      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense $ 1,808 $ 2,711 $ 2,365