Consolidated Statements Of Stockholders' Equity (Deficit) (USD $) In Thousands, except Share data, unless otherwise specified
|
Common Stock [Member]
|
Additional Paid-In Capital [Member]
|
Deferred Stock-Based Compensation [Member]
|
Accumulated Other Comprehensive Income (Loss) [Member]
|
Deficit Accumulated During The Development Stage [Member]
|
Total
|
Balances, value at Dec. 31, 2000 |
|
|
|
|
|
|
Issuance of restricted common stock to a founder and member of the Board of Directors for cash, value |
|
$ 2
|
|
|
|
$ 2
|
Issuance of restricted common stock to a founder and member of the Board of Directors for cash, shares |
25,300
|
|
|
|
|
|
Net loss |
|
|
|
|
(236)
|
(236)
|
Balances, value at Dec. 31, 2001 |
|
2
|
|
|
(236)
|
(234)
|
Balances, shares at Dec. 31, 2001 |
25,300
|
|
|
|
|
|
Issuance of restricted common stock to a founder and member of the Board of Directors for cash, value |
|
4
|
|
|
|
4
|
Issuance of restricted common stock to a founder and member of the Board of Directors for cash, shares |
3,795
|
|
|
|
|
|
Net loss |
|
|
|
|
(2,458)
|
(2,458)
|
Issuance of common stock pursuant to exercise of stock options for cash, shares |
405
|
|
|
|
|
|
Deferred stock-based compensation, net of cancellations |
|
25
|
(25)
|
|
|
|
Amortization of deferred stock-based compensation |
|
|
1
|
|
|
1
|
Non-employee stock-based compensation |
|
21
|
|
|
|
21
|
Components of other comprehensive income (loss): |
|
|
|
|
|
|
Change in unrealized gain (loss) on marketable securities |
|
|
|
(1)
|
|
(1)
|
Comprehensive loss |
|
|
|
|
|
(2,459)
|
Balances, value at Dec. 31, 2002 |
|
52
|
(24)
|
(1)
|
(2,694)
|
(2,667)
|
Balances, shares at Dec. 31, 2002 |
29,500
|
|
|
|
|
|
Net loss |
|
|
|
|
(8,303)
|
(8,303)
|
Issuance of common stock pursuant to exercise of stock options for cash, value |
|
1
|
|
|
|
1
|
Issuance of common stock pursuant to exercise of stock options for cash, shares |
1,285
|
|
|
|
|
|
Issuance of a warrant to purchase Series A redeemable convertible preferred stock |
|
44
|
|
|
|
44
|
Beneficial conversion feature related to issuance of Series B redeemable convertible preferred stock |
|
40,862
|
|
|
|
40,862
|
Deemed dividend related to beneficial conversion feature of Series B redeemable convertible preferred stock |
|
(40,862)
|
|
|
|
(40,862)
|
Deferred stock-based compensation, net of cancellations |
|
2,332
|
(2,332)
|
|
|
|
Amortization of deferred stock-based compensation |
|
|
810
|
|
|
810
|
Non-employee stock-based compensation |
|
256
|
|
|
|
256
|
Components of other comprehensive income (loss): |
|
|
|
|
|
|
Change in unrealized gain (loss) on marketable securities |
|
|
|
164
|
|
164
|
Comprehensive loss |
|
|
|
|
|
(8,139)
|
Balances, value at Dec. 31, 2003 |
|
2,685
|
(1,546)
|
163
|
(10,997)
|
(9,695)
|
Balances, shares at Dec. 31, 2003 |
30,785
|
|
|
|
|
|
Net loss |
|
|
|
|
(23,566)
|
(23,566)
|
Issuance of common stock pursuant to exercise of stock options for cash, value |
|
878
|
|
|
|
878
|
Issuance of common stock pursuant to exercise of stock options for cash, shares |
586,385
|
|
|
|
|
|
Deferred stock-based compensation, net of cancellations |
|
20,385
|
(20,385)
|
|
|
|
Amortization of deferred stock-based compensation |
|
|
5,294
|
|
|
5,294
|
Non-employee stock-based compensation |
|
681
|
|
|
|
681
|
Repurchase of unvested common stock, value |
|
(6)
|
|
|
|
(6)
|
Repurchase of unvested common stock, shares |
(2,073)
|
|
|
|
|
|
Components of other comprehensive income (loss): |
|
|
|
|
|
|
Change in unrealized gain (loss) on marketable securities |
|
|
|
(59)
|
|
(59)
|
Comprehensive loss |
|
|
|
|
|
(23,625)
|
Balances, value at Dec. 31, 2004 |
|
24,623
|
(16,637)
|
104
|
(34,563)
|
(26,473)
|
Balances, shares at Dec. 31, 2004 |
615,097
|
|
|
|
|
|
Issuance of restricted common stock to a founder and member of the Board of Directors for cash, shares |
1,018,768
|
|
|
|
|
|
Net loss |
|
|
|
|
(44,408)
|
(44,408)
|
Issuance of common stock in initial public offering for cash |
1
|
38,134
|
|
|
|
38,135
|
Issuance of common stock pursuant to exercise of stock options for cash, value |
1
|
62,394
|
|
|
|
62,395
|
Issuance of common stock pursuant to exercise of stock options for cash, shares |
1,066,537
|
|
|
|
|
|
Issuance of common stock pursuant to exercise of warrants, shares |
3,211
|
|
|
|
|
|
Conversion of convertible preferred stock upon initial public offering, value |
4
|
49,835
|
|
|
|
49,839
|
Conversion of convertible preferred stock upon initial public offering, shares |
3,425,468
|
|
|
|
|
|
Issuance of common stock pursuant to stock plans, value |
|
557
|
|
|
|
557
|
Issuance of common stock pursuant to stock plans, shares |
84,772
|
|
|
|
|
|
Deferred stock-based compensation, net of cancellations |
|
3,321
|
(3,321)
|
|
|
|
Reversal of deferred stock-based compensation related to employee terminations |
|
(2,862)
|
2,862
|
|
|
|
Amortization of deferred stock-based compensation |
|
(416)
|
5,740
|
|
|
5,324
|
Non-employee stock-based compensation |
|
4,097
|
|
|
|
4,097
|
Repurchase of unvested common stock, value |
|
(18)
|
|
|
|
(18)
|
Repurchase of unvested common stock, shares |
(8,591)
|
|
|
|
|
|
Components of other comprehensive income (loss): |
|
|
|
|
|
|
Change in unrealized gain (loss) on marketable securities |
|
|
|
(80)
|
|
(80)
|
Comprehensive loss |
|
|
|
|
|
(44,488)
|
Balances, value at Dec. 31, 2005 |
6
|
179,665
|
(11,356)
|
24
|
(78,971)
|
89,368
|
Balances, shares at Dec. 31, 2005 |
6,205,262
|
|
|
|
|
|
Net loss |
|
|
|
|
(55,686)
|
(55,686)
|
Issuance of common stock pursuant to stock plans, value |
|
518
|
|
|
|
518
|
Issuance of common stock pursuant to stock plans, shares |
46,144
|
|
|
|
|
|
Reversal of deferred stock-based compensation related to employee terminations |
|
(2,970)
|
2,970
|
|
|
|
Amortization of deferred stock-based compensation |
|
|
4,411
|
|
|
4,411
|
Stock-based compensation |
|
5,738
|
|
|
|
5,738
|
Repurchase of unvested common stock, value |
|
(80)
|
|
|
|
(80)
|
Repurchase of unvested common stock, shares |
(27,091)
|
|
|
|
|
|
Components of other comprehensive income (loss): |
|
|
|
|
|
|
Change in unrealized gain (loss) on marketable securities |
|
|
|
(31)
|
|
(31)
|
Comprehensive loss |
|
|
|
|
|
(55,717)
|
Balances, value at Dec. 31, 2006 |
6
|
182,871
|
(3,975)
|
(7)
|
(134,657)
|
44,238
|
Balances, shares at Dec. 31, 2006 |
6,224,315
|
|
|
|
|
|
Net loss |
|
|
|
|
(30,664)
|
(30,664)
|
Issuance of common stock pursuant to stock plans, value |
|
128
|
|
|
|
128
|
Issuance of common stock pursuant to stock plans, shares |
20,151
|
|
|
|
|
|
Reversal of deferred stock-based compensation related to employee terminations |
|
(304)
|
304
|
|
|
|
Amortization of deferred stock-based compensation |
|
|
2,837
|
|
|
2,837
|
Stock-based compensation |
|
3,072
|
|
|
|
3,072
|
Repurchase of unvested common stock, value |
|
(34)
|
|
|
|
(34)
|
Repurchase of unvested common stock, shares |
(16,410)
|
|
|
|
|
|
Components of other comprehensive income (loss): |
|
|
|
|
|
|
Change in unrealized gain (loss) on marketable securities |
|
|
|
10
|
|
10
|
Comprehensive loss |
|
|
|
|
|
(30,654)
|
Balances, value at Dec. 31, 2007 |
6
|
185,733
|
(834)
|
3
|
(165,321)
|
19,587
|
Balances, shares at Dec. 31, 2007 |
6,228,056
|
|
|
|
|
|
Net loss |
|
|
|
|
(18,292)
|
(18,292)
|
Issuance of common stock and warrants to certain investors, net of issuance costs, value |
9
|
16,812
|
|
|
|
16,821
|
Issuance of common stock and warrants to certain investors, net of issuance costs, shares |
8,970,574
|
|
|
|
|
|
Issuance of common stock pursuant to stock plans, value |
|
30
|
|
|
|
30
|
Issuance of common stock pursuant to stock plans, shares |
15,461
|
|
|
|
|
|
Amortization of deferred stock-based compensation |
|
|
828
|
|
|
828
|
Stock-based compensation |
|
2,424
|
|
|
|
2,424
|
Repurchase of unvested common stock, shares |
(47)
|
|
|
|
|
|
Components of other comprehensive income (loss): |
|
|
|
|
|
|
Change in unrealized gain (loss) on marketable securities |
|
|
|
16
|
|
16
|
Comprehensive loss |
|
|
|
|
|
(18,276)
|
Balances, value at Dec. 31, 2008 |
15
|
204,999
|
(6)
|
19
|
(183,613)
|
21,414
|
Balances, shares at Dec. 31, 2008 |
15,214,044
|
|
|
|
|
|
Net loss |
|
|
|
|
(23,648)
|
(23,648)
|
Issuance of common stock and warrants to certain investors, net of issuance costs, value |
18
|
23,210
|
|
|
|
23,228
|
Issuance of common stock and warrants to certain investors, net of issuance costs, shares |
18,324,599
|
|
|
|
|
|
Issuance of common stock pursuant to stock plans, value |
|
27
|
|
|
|
27
|
Issuance of common stock pursuant to stock plans, shares |
25,027
|
|
|
|
|
|
Amortization of deferred stock-based compensation |
|
|
6
|
|
|
6
|
Stock-based compensation |
|
2,205
|
|
|
|
2,205
|
Cumulative effect of change in accounting principle |
|
|
|
|
(532)
|
(532)
|
Components of other comprehensive income (loss): |
|
|
|
|
|
|
Change in unrealized gain (loss) on marketable securities |
|
|
|
(43)
|
|
(43)
|
Comprehensive loss |
|
|
|
|
|
(23,691)
|
Balances, value at Dec. 31, 2009 |
33
|
230,441
|
|
(24)
|
(207,793)
|
22,657
|
Balances, shares at Dec. 31, 2009 |
33,563,670
|
|
|
|
|
|
Net loss |
|
|
|
|
(18,682)
|
(18,682)
|
Issuance of common stock pursuant to stock plans, value |
1
|
139
|
|
|
|
140
|
Issuance of common stock pursuant to stock plans, shares |
138,572
|
|
|
|
|
|
Stock-based compensation |
|
803
|
|
|
|
803
|
Components of other comprehensive income (loss): |
|
|
|
|
|
|
Change in unrealized gain (loss) on marketable securities |
|
|
|
25
|
|
25
|
Comprehensive loss |
|
|
|
|
|
(18,657)
|
Balances, value at Dec. 31, 2010 |
34
|
231,383
|
|
1
|
(226,475)
|
4,943
|
Balances, shares at Dec. 31, 2010 |
33,702,242
|
|
|
|
|
33,702,242
|
Net loss |
|
|
|
|
(25,653)
|
(25,653)
|
Issuance of common stock and warrants to certain investors, net of issuance costs, value |
15
|
23,992
|
|
|
|
24,007
|
Issuance of common stock and warrants to certain investors, net of issuance costs, shares |
15,284,118
|
|
|
|
|
|
Issuance of common stock pursuant to stock plans, value |
|
149
|
|
|
|
149
|
Issuance of common stock pursuant to stock plans, shares |
142,115
|
|
|
|
|
|
Stock-based compensation |
|
1,039
|
|
|
|
1,039
|
Components of other comprehensive income (loss): |
|
|
|
|
|
|
Change in unrealized gain (loss) on marketable securities |
|
|
|
(2)
|
|
(2)
|
Comprehensive loss |
|
|
|
|
|
(26,655)
|
Balances, value at Dec. 31, 2011 |
$ 49
|
$ 256,563
|
|
$ (1)
|
$ (252,128)
|
$ 4,483
|
Balances, shares at Dec. 31, 2011 |
49,128,475
|
|
|
|
|
49,128,475
|