Quarterly report pursuant to Section 13 or 15(d)

Research and Development Agreements - Schedule of Research and Development Revenues Disaggregated by Location (Detail)

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Research and Development Agreements - Schedule of Research and Development Revenues Disaggregated by Location (Detail) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Revenue Recognition [Line Items]        
Total research and development revenue $ 4,417 $ 15,134 $ 12,903 $ 18,354
JAPAN        
Revenue Recognition [Line Items]        
Total research and development revenue 0 12,899 2,586 13,136
UNITED STATES        
Revenue Recognition [Line Items]        
Total research and development revenue $ 4,417 $ 2,235 $ 10,317 $ 5,218