Annual report pursuant to Section 13 and 15(d)

Stockholders' Equity - Additional Information (Detail)

v3.22.1
Stockholders' Equity - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 12 Months Ended
Aug. 07, 2020
Nov. 25, 2019
Sep. 25, 2018
Feb. 28, 2018
Feb. 27, 2018
Aug. 01, 2017
Jun. 23, 2017
Feb. 28, 2021
Jul. 31, 2020
Dec. 31, 2017
Dec. 31, 2021
Dec. 31, 2020
Class Of Warrant Or Right [Line Items]                        
Net proceeds from common stock                     $ 71,145 $ 48,372
Preferred stock, par value                     $ 0.001 $ 0.001
Sale of securities $ 300,000                      
Term Loan Facility | Perceptive Credit Facility                        
Class Of Warrant Or Right [Line Items]                        
Warrant exercisable period         7 years              
Common stock exercise price         $ 9.5792              
Number of shares to be issued upon exercise of warrant         190,000              
Series A Convertible Preferred Stock                        
Class Of Warrant Or Right [Line Items]                        
Number of shares sold   250                    
Shares issued, price per share   $ 8.00                    
Preferred stock, conversion basis                     Each share of Series A Preferred Stock is convertible to 1,000 shares of Common Stock, provided that the holder of Series A Preferred Stock will be prohibited from converting the Series A Preferred Stock into shares of common stock if, as a result of such conversion, the holder, together with its affiliates, would own more than 9.99% of the total number of shares of the Company’s common stock then issued and outstanding.  
Number of preferred stock converted into common stock   1,000                    
Minimum holding percentage of common stock issued and outstanding upon conversion   9.99%                    
Preferred stock, par value   $ 0.001                    
Preferred Stock , voting rights description                     The Series A Preferred Stock has no voting rights, except as required by law and except that the consent of the Series A Preferred Stockholders will be required to amend the terms of the Series A Preferred Stock.  
Preferred stock beneficial conversion feature intrinsic value   $ 700                    
Common Stock | Term Loan Facility | Perceptive Credit Facility                        
Class Of Warrant Or Right [Line Items]                        
Warrant exercisable period       7 years                
Common stock exercise price       $ 9.58                
Valuation of equity classified warrants recorded in additional paid-n capital       $ 1,500                
Expected dividend rate       0.00%                
Expected volatility       105.00%                
Risk free interest rate       2.80%                
Expected term       7 years                
Number of shares to be issued upon exercise of warrant       190,000                
Wedbush Agreement                        
Class Of Warrant Or Right [Line Items]                        
Valuation of equity classified warrants recorded in additional paid-n capital                   $ 400    
Expected dividend rate                   0.00%    
Expected volatility                   108.00%    
Risk free interest rate                   2.30%    
Expected term                   7 years    
Takeda Pharmaceuticals Inc                        
Class Of Warrant Or Right [Line Items]                        
Aggregate purchase price             $ 20,000          
Each unit of shares transaction of common stock             2,922,993          
Purchase price per share             $ 6.8423          
Vertex Pharmaceuticals Inc                        
Class Of Warrant Or Right [Line Items]                        
Aggregate purchase price             $ 15,000          
Each unit of shares transaction of common stock             1,666,666          
Purchase price per share             $ 9.00          
Private Placement | Common Stock                        
Class Of Warrant Or Right [Line Items]                        
Valuation of equity classified warrants recorded in additional paid-n capital           $ 16,300            
Expected dividend rate           0.00%            
Expected volatility           147.00%            
Risk free interest rate           2.07%            
Expected term           7 years            
Private Placement | Longitude Venture Partners III, L.P.                        
Class Of Warrant Or Right [Line Items]                        
Number of aggregate units sold           5,793,063            
Aggregate purchase price           $ 40,000            
Each unit of shares transaction of common stock           1            
Warrants to purchase shares of common stock           0.5            
Sale of units, description and its composition                     the Company sold an aggregate of 5,793,063 units (the “Units”) having an aggregate purchase price of $40.0 million (“PIPE Financing”), each such Unit consisting of (i) one (1) share (the “Shares”) of our common stock and (ii) a warrant (the “Private Placement Warrants”) to purchase 0.5 shares of our common stock (the “Private Placement”).  
Purchase price per unit           $ 6.9048            
Warrant exercisable period           7 years            
Common stock exercise price           $ 6.8423            
Private Placement | Longitude Venture Partners III, L.P. | Common Stock                        
Class Of Warrant Or Right [Line Items]                        
Warrants to purchase shares of common stock                     2,896,528  
Private Placement | Wedbush Agreement | Common Stock                        
Class Of Warrant Or Right [Line Items]                        
Warrants to purchase shares of common stock                   57,930 57,930  
Warrant exercisable period                   7 years    
Common stock exercise price                   $ 6.8423    
Underwritten Public Offering                        
Class Of Warrant Or Right [Line Items]                        
Number of shares sold     9,430,000                  
Shares issued, price per share     $ 5.50                  
Net proceeds from common stock     $ 48,100                  
Over Allotment Option                        
Class Of Warrant Or Right [Line Items]                        
Number of shares sold   900,000 1,230,000                  
2019 Underwritten Public Offering                        
Class Of Warrant Or Right [Line Items]                        
Number of shares sold   6,900,000                    
Shares issued, price per share   $ 8.00                    
Net proceeds from common stock   $ 53,400                    
At-the-market Offering                        
Class Of Warrant Or Right [Line Items]                        
Net proceeds from common stock $ 100,000               $ 48,500      
Gross proceeds from common stock                 $ 50,000      
Sale of securities                     $ 71,145 $ 48,372
At-the-market Offering | Common Stock                        
Class Of Warrant Or Right [Line Items]                        
Number of shares sold                     6,000,000 4,133,916
Sale of securities                     $ 6 $ 4
At-the-market Offering | Common Stock at Purchase Price of $12.00 Per Share                        
Class Of Warrant Or Right [Line Items]                        
Purchase price per share                 $ 12.00      
Number of shares sold                 3,600,000      
At-the-market Offering | Common Stock at Purchase Price of $12.70 Per Share                        
Class Of Warrant Or Right [Line Items]                        
Purchase price per share                 $ 12.70      
Number of shares sold                 500,000      
Public Offering                        
Class Of Warrant Or Right [Line Items]                        
Number of shares sold               6,000,000.0        
Shares issued, price per share               $ 12.65        
Net proceeds from common stock               $ 71,100