Annual report pursuant to Section 13 and 15(d)

Research and Development Agreements - Schedule of Research and Development Revenue from Related Party Relates to Revenue from Research and Development Agreements (Detail)

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Research and Development Agreements - Schedule of Research and Development Revenue from Related Party Relates to Revenue from Research and Development Agreements (Detail) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Jun. 30, 2021
Dec. 31, 2021
Dec. 31, 2020
Revenue Recognition [Line Items]      
Total research and development revenue, related party   $ 38,697 $ 15,635
Takeda Development Agreement      
Revenue Recognition [Line Items]      
Total research and development revenue, related party $ 12,900    
Millennium Pharmaceuticals Inc      
Revenue Recognition [Line Items]      
Total research and development revenue, related party   13,136 6,567
Millennium Pharmaceuticals Inc | Takeda Development Agreement      
Revenue Recognition [Line Items]      
Total research and development revenue, related party   13,114 6,068
Millennium Pharmaceuticals Inc | Takeda Multi Target Agreement      
Revenue Recognition [Line Items]      
Total research and development revenue, related party   $ 22 $ 499