SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Schedule 13G
INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b),
(c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b)
(Amendment No. __)*
Threshold Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
(Name of Issuer)
Common Stock
- --------------------------------------------------------------------------------
(Title of Class of Securities)
885807107
- --------------------------------------------------------------------------------
(CUSIP Number)
December 31, 2005
- --------------------------------------------------------------------------------
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:
[ ] Rule 13d-1(b)
[ ] Rule 13d-1(c)
[X] Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
Page 1 of 15 Pages
Exhibit Index Contained on Page 14
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CUSIP NO. 12345A678 13 G Page 2 of 15
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- ------------ ---------------------------------------------------------------------------------------------------------
1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (Entities Only).
Sofinnova Venture Partners V, L.P. ("SVP V")
- ------------ ---------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) (b) X
- ------------ ---------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
- ------------ ---------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- ------------ ---------------------------------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF 3,281,905 shares, except that Sofinnova Management V, L.L.C. ("SM V")
SHARES and Sofinnova Management V 2005 L.L.C. ("SMV 2005"), the general
BENEFICIALLY partners of SVP V, may be deemed to have shared voting power, and
OWNED BY EACH REPORTING Michael F. Powell ("Powell"), Alain L. Azan ("Azan") and James I.
PERSON Healy, M.D., Ph.D. ("Healy"), the managing members of SM V and SMV
WITH 2005, may be deemed to have shared power to vote these shares.
-------- ------------------------------------------------------------------------
6 SHARED VOTING POWER
See response to row 5.
-------- ------------------------------------------------------------------------
7 SOLE DISPOSITIVE POWER
3,281,905 shares, except that SM V and SMV 2005, the general partners
of SVP V, may be deemed to have shared dispositive power and Powell,
Azan and Healy, the managing members of SM V and SMV 2005, may be
deemed to have shared power to dispose of these shares.
-------- ------------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
See response to row 7.
- ------------------------------------ -------- ------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON 3,281,905
- ------------ ---------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (See Instructions) [ ]
- ------------ ---------------------------------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
8.8%
- ------------ ---------------------------------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (See Instructions)
PN
- ------------ ---------------------------------------------------------------------------------------------------------
- ---------------------------------------------------------- --------------------------------------
CUSIP NO. 12345A678 13 G Page 3 of 15
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- ------------ ---------------------------------------------------------------------------------------------------------
1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (Entities Only).
Sofinnova Venture Affiliates V, L.P. ("SVA V")
- ------------ ---------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) (b) X
- ------------ ---------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
- ------------ ---------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- ------------ ---------------------------------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF 107,974 shares, except that SM V, the general partner of SVA V, may be
SHARES deemed to have sole voting power, and Powell, Azan and Healy, the
BENEFICIALLY managing members of SM V, may be deemed to have shared power to vote
OWNED BY EACH REPORTING these shares.
PERSON
WITH
-------- ------------------------------------------------------------------------
6 SHARED VOTING POWER
See response to row 5.
-------- ------------------------------------------------------------------------
7 SOLE DISPOSITIVE POWER
107,974 shares, except that SM V, the general partner of SVA V, may be
deemed to have sole dispositive power, and Powell, Azan and Healy, the
managing members of SM V, may be deemed to have shared power to
dispose of these shares.
-------- ------------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
See response to row 7.
- ------------------------------------ -------- ------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON 107,974
- ------------ ---------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (See Instructions) [ ]
- ------------ ---------------------------------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
0.3%
- ------------ ---------------------------------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (See Instructions)
PN
- ------------ ---------------------------------------------------------------------------------------------------------
- ---------------------------------------------------------- --------------------------------------
CUSIP NO. 12345A678 13 G Page 4 of 15
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1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (Entities Only).
Sofinnova Venture Principals V, LP ("SVPr V")
- ------------ ---------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) (b) X
- ------------ ---------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
- ------------ ---------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- ------------ ---------------------------------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF 50,321 shares, except that SM V, the general partner of SVPr V, may be
SHARES deemed to have sole voting power, and Powell, Azan and Healy, the
BENEFICIALLY managing members of SM V, may be deemed to have shared power to vote
OWNED BY EACH REPORTING these shares.
PERSON
WITH
-------- ------------------------------------------------------------------------
6 SHARED VOTING POWER
See response to row 5.
-------- ------------------------------------------------------------------------
7 SOLE DISPOSITIVE POWER
50,321 shares, except that SM V, the general partner of SVPr V, may be
deemed to have sole dispositive power, and Powell, Azan and Healy, the
managing members of SM V, may be deemed to have shared power to
dispose of these shares.
-------- ------------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
See response to row 7.
- ------------------------------------ -------- ------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON 50,321
- ------------ ---------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (See Instructions) [ ]
- ------------ ---------------------------------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
0.1%
- ------------ ---------------------------------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (See Instructions)
PN
- ------------ ---------------------------------------------------------------------------------------------------------
- ---------------------------------------------------------- --------------------------------------
CUSIP NO. 12345A678 13 G Page 5 of 15
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- ------------ ---------------------------------------------------------------------------------------------------------
1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (Entities Only).
Sofinnova Management V, L.L.C. ("SM V")
- ------------ ---------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) (b) X
- ------------ ---------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
- ------------ ---------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- ------------ ---------------------------------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF
SHARES 158,295 shares, of which 107,974 shares are owned directly by SVA V
BENEFICIALLY and 50,321 shares are owned directly by SVPr V. SM V, the general
OWNED BY EACH REPORTING partner of SVA V and SVPr V, may be deemed to have sole voting over
PERSON the shares owned directly by SVA V and SVPr V, and Powell, Azan and
WITH Healy, the managing members of SM V, may be deemed to have shared
power to vote these shares.
-------- ------------------------------------------------------------------------
6 SHARED VOTING POWER
3,281,905 shares owned directly by SVP V. SM V and SM V 2005, the
general partners of SVP V, may be deemed to have shared voting power
over the shares owned directly by SVA V, and Powell, Azan and Healy,
the managing members of both SM V and SM V 2005, may be deemed to have
shared power to vote these shares.
-------- ------------------------------------------------------------------------
7 SOLE DISPOSITIVE POWER
158,295 shares, of which 107,974 shares are owned directly by SVA V
and 50,321 shares are owned directly by SVPr V. SM V, the general
partner of SVA V and SVPr V, may be deemed to have sole dispositive
power over the shares owned directly by SVA V and SVPr V, and Powell,
Azan and Healy, the managing members of SM V, may be deemed to have
shared power to dispose of these shares.
-------- ------------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
3,281,905 shares owned directly by SVP V. SM V and SM V 2005, the
general partners of SVP V, may be deemed to have shared dispositive
power over the shares owned directly by SVA V, and Powell, Azan and
Healy, the managing members of both SM V and SM V 2005, may be deemed
to have shared power to dispose of these shares.
- ------------------------------------ -------- ------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON 3,440,200
- ------------ ---------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (See Instructions) [ ]
- ------------ ---------------------------------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
9.2%
- ------------ ---------------------------------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (See Instructions)
OO
- ------------ ---------------------------------------------------------------------------------------------------------
- ---------------------------------------------------------- --------------------------------------
CUSIP NO. 12345A678 13 G Page 6 of 15
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- ------------ ---------------------------------------------------------------------------------------------------------
1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (Entities Only).
Sofinnova Management V 2005 L.L.C. ("SMV 2005")
- ------------ ---------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) (b) X
- ------------ ---------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
- ------------ ---------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- ------------ ---------------------------------------------------------------------------------------------------------
5 SOLE VOTING POWER
NUMBER OF 0
SHARES
BENEFICIALLY
OWNED BY EACH REPORTING
PERSON
WITH
-------- ------------------------------------------------------------------------
6 SHARED VOTING POWER
3,281,905 shares which are owned directly by SVP V. SMV 2005 and SM
V, the general partners of SVP V, may be deemed to have shared voting
power, and Powell, Azan and Healy, the managing members of SMV 2005
and SM V, may be deemed to have shared power to vote these shares.
-------- ------------------------------------------------------------------------
7 SOLE DISPOSITIVE POWER
0
-------- ------------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
3,281,905 shares which are owned directly by SVP V. SMV 2005 and SM
V, the general partners of SVP V, may be deemed to have shared
dispositive power, and Powell, Azan and Healy, the managing members of
SMV 2005 and SM V, may be deemed to have shared power to dispose of
these shares.
- ------------------------------------ -------- ------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON 3,281,905
- ------------ ---------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (See Instructions) [ ]
- ------------ ---------------------------------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
8.8%
- ------------ ---------------------------------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (See Instructions)
OO
- ------------ ---------------------------------------------------------------------------------------------------------
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CUSIP NO. 12345A678 13 G Page 7 of 15
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1 NAME OF REPORTING
SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Michael F. Powell ("Powell")
Tax ID Number:
- ------------ --------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) (b) X
- ------------ --------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
- ------------ --------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S. Citizen
- ------------ --------------------------------------------------------------------------------------------------------
5 SOLE VOTING POWER
11,250 shares (issuable to Powell pursuant to outstanding options
NUMBER OF exercisable within 60 days of December 31, 2005).
SHARES -------- -----------------------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY EACH REPORTING 3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
PERSON V, 107,974 shares are owned directly by SVA V and 50,321 shares are
WITH owned directly by SVPr V. SM V is the general partner of SVA V and
SVPr V, and Powell, a managing member of SM V, may be deemed to have
shared power to vote the shares held by SVA V and SVPr V. SM V and
SMV 2005 are general partners of SVP V, and Powell, a managing member
of both SM V and SMV 2005, may be deemed to have shared power to vote
the shares held by SVP V.
-------- -----------------------------------------------------------------------
7 SOLE DISPOSITIVE POWER
11,250 shares (issuable to Powell pursuant to outstanding options
exercisable within 60 days of December 31, 2005).
-------- -----------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
V, 107,974 shares are owned directly by SVA V and 50,321 shares are
owned directly by SVPr V. SM V is the general partner of SVA V and
SVPr V, and Powell, a managing member of SM V, may be deemed to have
shared power to dispose of the shares held by SVA V and SVPr V. SM V
and SMV 2005 are general partners of SVP V, and Powell, a managing
member of both SM V and SMV 2005, may be deemed to have shared power
to dispose of the shares held by SVP V.
- ------------------------------------ -------- -----------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON 3,451,450 shares.
- ------------ --------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES* [ ]
- ------------ --------------------------------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
9.3%
- ------------ --------------------------------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- ----------- --------------------------------------------------------------------------------------------------------
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CUSIP NO. 12345A678 13 G Page 8 of 15
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1 NAME OF REPORTING
SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Alain L. Azan ("Azan")
Tax ID Number:
- ------------ --------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) (b) X
- ------------ --------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
- ------------ --------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S. Citizen
- ------------ --------------------------------------------------------------------------------------------------------
5 SOLE VOTING POWER
0 shares.
NUMBER OF
SHARES -------- -----------------------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY EACH REPORTING 3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
PERSON V, 107,974 shares are owned directly by SVA V and 50,321 shares are
WITH owned directly by SVPr V. SM V is the general partner of SVA V and
SVPr V, and Azan, a managing member of SM V, may be deemed to have
shared power to vote the shares held by SVA V and SVPr V. SM V and
SMV 2005 are general partners of SVP V, and Azan, a managing member
of both SM V and SMV 2005, may be deemed to have shared power to vote
the shares held by SVP V.
-------- -----------------------------------------------------------------------
7 SOLE DISPOSITIVE POWER
0 shares
-------- -----------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
V, 107,974 shares are owned directly by SVA V and 50,321 shares are
owned directly by SVPr V. SM V is the general partner of SVA V and
SVPr V, and Azan, a managing member of SM V, may be deemed to have
shared power to dispose of the shares held by SVA V and SVPr V. SM V
and SMV 2005 are general partners of SVP V, and Azan, a managing
member of both SM V and SMV 2005, may be deemed to have shared power
to dispose of the shares held by SVP V.
- ------------------------------------ -------- -----------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON 3,440,200 shares.
- ------------ --------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES* [ ]
- ------------ --------------------------------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
9.2%
- ------------ --------------------------------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- ------------ --------------------------------------------------------------------------------------------------------
- ---------------------------------------------------------- --------------------------------------
CUSIP NO. 12345A678 13 G Page 9 of 15
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- ------------ --------------------------------------------------------------------------------------------------------
1 NAME OF REPORTING
SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
James I. Healy, M.D., Ph.D. ("Healy")
Tax ID Number:
- ------------ --------------------------------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) (b) X
- ------------ --------------------------------------------------------------------------------------------------------
3 SEC USE ONLY
- ------------ --------------------------------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S. Citizen
- ------------ --------------------------------------------------------------------------------------------------------
5 SOLE VOTING POWER
0 shares.
NUMBER OF
SHARES -------- -----------------------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY EACH REPORTING 3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
PERSON V, 107,974 shares are owned directly by SVA V and 50,321 shares are
WITH owned directly by SVPr V. SM V is the general partner of SVA V and
SVPr V, and Healey, a managing member of SM V, may be deemed to have
shared power to vote the shares held by SVA V and SVPr V. SM V and
SMV 2005 are general partners of SVP V, and Healey, a managing member
of both SM V and SMV 2005, may be deemed to have shared power to vote
the shares held by SVP V.
-------- -----------------------------------------------------------------------
7 SOLE DISPOSITIVE POWER
0 shares
-------- -----------------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
3,440,200 shares, of which 3,281,905 shares are owned directly by SVP
V, 107,974 shares are owned directly by SVA V and 50,321 shares are
owned directly by SVPr V. SM V is the general partner of SVA V and
SVPr V, and Healey, a managing member of SM V, may be deemed to have
shared power to dispose of the shares held by SVA V and SVPr V. SM V
and SMV 2005 are general partners of SVP V, and Healey, a managing
member of both SM V and SMV 2005, may be deemed to have shared power
to dispose of the shares held by SVP V.
- ------------------------------------ -------- -----------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON 3,440,200 shares.
- ------------ --------------------------------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES* [ ]
- ------------ --------------------------------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
9.2%
- ------------ --------------------------------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- ------------ --------------------------------------------------------------------------------------------------------
- ------------------------------------ -----------------------
CUSIP NO. 12345A678 13 G Page 10 of 15
- ------------------------------------ -----------------------
ITEM 1(A). NAME OF ISSUER
--------------
Threshold Pharmaceuticals, Inc.
ITEM 1(B). ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES
-----------------------------------------------
1300 Seaport Boulevard
Redwood City, CA 94063
ITEM 2(A). NAME OF PERSONS FILING
----------------------
This Statement is filed by Sofinnova Venture Partners V, L.P.
("SVP V"), Sofinnova Venture Affiliates V, L.P. ("SVA V"),
Sofinnova Venture Principals V, L.P. ("SVPr V"), Sofinnova
Management V, L.L.C. ("SM V"), Sofinnova Management V 2005 LLC
("SMV 2005"), Michael F. Powell ("Powell"), Alain L. Azan
("Azan") and James I. Healy, M.D., Ph.D. ("Healey") (the
"Reporting Person"). The foregoing entities and individuals
are collectively referred to as the "Reporting Persons."
SM V, the general partner of SVA V and SVPr V, may be deemed
to have sole power to vote and sole power to dispose of shares
of the issuer directly owned by SVA V and SVPr V. Powell, Azan
and Healey are the managing members of SM V and may be deemed
to have shared power to vote and shared power to dispose of
shares of the issuer directly owned by SVA V and SVPr V.
SM V and SMV 2005, the general partners of SVP V, may be
deemed to have shared power to vote and shared power to
dispose of shares of the issuer directly owned by SVP V.
Powell, Azan and Healey are the managing members of SMV and
SMV 2005 and may be deemed to have shared power to vote and
shared power to dispose of shares of the issuer directly owned
by SVP V.
ITEM 2(B). ADDRESS OF PRINCIPAL BUSINESS OFFICE
------------------------------------
The address for each of the Reporting Persons is:
Sofinnova Ventures Inc.
140 Geary Street, 10th Floor
San Francisco, California 94108
ITEM 2(C) CITIZENSHIP
-----------
SVP V, SVA V and SVPr V, are Delaware limited partnerships. SM
V and SMV 2005 are a Delaware limited liability companies.
Powell, Azan and Healy are United States citizens.
ITEM 2(D) AND (E). TITLE OF CLASS OF SECURITIES AND CUSIP NUMBER
---------------------------------------------
Common Stock
CUSIP # 885807-107
ITEM 3. Not Applicable.
---------------
ITEM 4. OWNERSHIP
---------
Provide the following information regarding the aggregate
number and percentage of the class of securities of the issuer
identified in Item 1.
- ------------------------------------ -----------------------
CUSIP NO. 12345A678 13 G Page 11 of 15
- ------------------------------------ -----------------------
(a) Amount beneficially owned:
--------------------------
See Row 9 of cover page for each Reporting Person.
(b) Percent of Class:
-----------------
See Row 11 of cover page for each Reporting Person.
(c) Number of shares as to which such person has:
---------------------------------------------
(i) Sole power to vote or to direct the vote:
-----------------------------------------
See Row 5 of cover page for each
Reporting Person.
(ii) Shared power to vote or to direct the
----------------------------------------
vote:
-----
See Row 6 of cover page for each
Reporting Person.
(iii) Sole power to dispose or to direct the
----------------------------------------
disposition of:
---------------
See Row 7 of cover page for each
Reporting Person.
(iv) Shared power to dispose or to direct the
-----------------------------------------
disposition of:
---------------
See Row 8 of cover page for each
Reporting Person.
ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS
--------------------------------------------
Not applicable.
ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER
--------------------------------------------------------------
PERSON.
-------
Under certain circumstances set forth in the limited
partnership agreements of SVP V, SVA V and SVPr V, and the
limited liability company agreements of SM V and SMV 2005, the
general and limited partners or members, as the case may be,
of each of such entities may be deemed to have the right to
receive dividends from, or the proceeds from, the sale of
shares of the issuer owned by each such entity of which they
are a partner or member, as the case may be.
- ------------------------------------ -----------------------
CUSIP NO. 12345A678 13 G Page 12 of 15
- ------------------------------------ -----------------------
ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
--------------------------------------------------------------
ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
--------------------------------------------------------------
COMPANY
-------
Not applicable.
ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.
----------------------------------------------------------
Not applicable.
ITEM 9. NOTICE OF DISSOLUTION OF GROUP.
-------------------------------
Not applicable.
ITEM 10. CERTIFICATION.
--------------
Not applicable.
- ------------------------------------ -----------------------
CUSIP NO. 12345A678 13 G Page 13 of 15
- ------------------------------------ -----------------------
SIGNATURES
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
Date: February __, 2006
Sofinnova Venture Partners V, L.P. /s/ James I. Healy
By Sofinnova Management V, L.L.C. ----------------------------
By Sofinnova Management V 2005 L.L.C. James I. Healy, Member
Its General Partners
Sofinnova Venture Affiliates V, L.P. /s/ James I. Healy
By Sofinnova Management V, L.L.C. ----------------------------
Its General Partner James I. Healy, Member
Sofinnova Venture Principals V, L.P. /s/ James I. Healy
By Sofinnova Management V, L.L.C. ----------------------------
Its General Partner James I. Healy, Member
Michael F. Powell /s/ Michael F. Powell
----------------------------
Michael F. Powell
Alain L. Azan /s/ Alain L. Azan
----------------------------
Alain L. Azan
James I. Healey, M.D., Ph.D. /s/ James I. Healey
----------------------------
James I. Healey
The original statement shall be signed by each person on whose behalf the
statement is filed or his authorized representative. If the statement is signed
on behalf of a person by his authorized representative other than an executive
officer or general partner of the filing person, evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement, provided, however, that a power of attorney for this purpose
which is already on file with the Commission may be incorporated by reference.
The name and any title of each person who signs the statement shall be typed or
printed beneath his signature. NOTE: Schedules filed in paper format shall
include a signed original and five copies of the schedule, including all
exhibits. See ss.240.13d-7 for other parties for whom copies are to be sent.
Attention: Intentional misstatements or omissions of fact constitute Federal
criminal violations (See 18 U.S.C. 1001)
- ------------------------------------ -----------------------
CUSIP NO. 12345A678 13 G Page 14 of 15
- ------------------------------------ -----------------------
EXHIBIT INDEX
-------------
Found on
Sequentially
Exhibit Numbered Page
- ------- -------------
Exhibit A: Agreement of Joint Filing 19
- ------------------------------------ -----------------------
CUSIP NO. 12345A678 13 G Page 15 of 15
- ------------------------------------ -----------------------
EXHIBIT A
---------
Agreement of Joint Filing
-------------------------
The undersigned hereby agree that a single Schedule 13G (or any amendment
thereto) relating to the Common Stock of Threshold Pharmaceuticals, Inc. shall
be filed on behalf of each of the undersigned and that this Agreement shall be
filed as an exhibit to such Schedule 13G.
Date: February __, 2006
Sofinnova Venture Partners V, L.P. /s/ James I. Healey
By Sofinnova Management V, L.L.C. ----------------------------
By Sofinnova Management V 2005 L.L.C. James I. Healy, Member
Its General Partners
Sofinnova Venture Affiliates V, L.P. /s/ James I. Healey
By Sofinnova Management V, L.L.C. ----------------------------
Its General Partner James I. Healy, Member
Sofinnova Venture Principals V, L.P. /s/ James I. Healey
By Sofinnova Management V, L.L.C. ----------------------------
Its General Partner James I. Healy, Member
Michael F. Powell /s/ Michael F. Powell
----------------------------
Michael F. Powell
Alain L. Azan /s/ Alain L. Azan
----------------------------
Alain L. Azan
James I. Healey, M.D., Ph.D. /s/ James I. Healey
----------------------------
James I. Healey